I know this comes up repeatedly, but here's my two cents on it. I love IN for cooperative patients. Fentanyl seems to work well since they want the medication and can follow your instructions fairly well (IE, not sneeze it back all over you). IN Versed for sedation or seizure? Not as awesome, particularly since I'd have to have my hand close to the combative patient's mouth. I've had good experience with IN Narcan, but it takes far longer and we often grow impatient. I find myself using IN most of the time as a "hold over" route until I place an IV. For example, I'll give a little bit of IN Fentanyl prior to moving the old lady, then finish with IV Fentanyl in the ambulance, or a touch of IN Narcan as my partner grabs a line. For Versed, I just go IM and don't bother with any other nonsense.