Clare
Forum Asst. Chief
- 790
- 83
- 28
Nice article, but I don't feel like it answered my question. If epinephrine normally causes vasodilation, why does it cause vasospasms at therapeutic doses in these patients? Why are they more at risk if they have CAD compared to somebody young and without CAD? In your article, it mentioned three patients who were relatively young and without CAD, and made it seem like epi induced MI is rare. I also liked how they tried to argue that epi IV probably caused less myocardial damage. Some interesting stuff.
Adrenaline causes profound vasoconstriction. The aetiology of acute myocardial ischaemia/acute myocardial infarction from adrenaline administration is the increased myocardial oxygen requirements due to the beta agonist effects; basically think of it as exertional angina in an ampoule; in a patient with pre-existing coronary artery disease the potential for this is going to be greater.
Having said that, the balance of risk is always in favour of giving adrenaline vs. not;; but if the person already has coronary artery disease then a reduced dose might be a good idea.
I never did figure what I wrote on my hand, its almost completely faded, but like I said, points to anybody who can figure it out, I don't usually write on my hand so it was probably important!