Fluid res itself will be tocolytic in this patient. administration of roughly 1L of fluid, intravenously, increases the intravascular fluid volume,which inhibits ADH secretion from the neurohypophysis. since oxytocin and ADh are secreted from the same area of the pituatary gland, inhibition of ADH secretion also inhibits oxytocin release, causing uterine contractions to stop.
(a poor choice for this particular patient)
Sedation of the patient, with narcs or barbituates allows the patient to rest. Often, after a period of "rest", contractions will stop on their own.
Generally, tocolysis in the field is limited to sedation, and hydration. though a last ditch effort, magnesium sulfate, or a beta agonist such as terbutaline or ritdrine may be administered to stop labor by inhibiting uterine smooth muscle contraction
I just stumbled over this post, so I know this is both late and in general not a major consideration for the treatment of this patient, but I though anyone who though deeply enough about that effect of hydration on OT might find this interesting:
I'm very curious if what you say about the inhibition of oxytocin is correct. I'd caution you about generalizing about the combined control of Vasopressin (VP) and Oxytocin (OT). Though they are both released from the posterior pituitary, the control of the two is not
necissarily intertwined. I don't think anyone knows specifically how control works in the humans.
Most of the research relating to the control of VP/OT release under conditions of hypovolemia was done in a rat model in the context of studies focusing on plasma osmolality as well. A few of these were also done in dogs.
In the setting of osmolality, it was found that in a rat an increase in plasma osmolality (pOsm) increased secretion of VP into the bloodstream accompanied by OT. However, in dogs, it was found that ONLY VP was secreted....OT was unaffected by an increase in pOsm. Thus VP and OT are are not necessarily controlled by the same mechanisms in all circumstances, and there are differences across species, even among mammals.
Unfortunately, in the realm of hypoVOLEMIA, I am not aware of any dog research that addresses the issue of differential control of VP and OT. It is true that in a rat hypovolemia leads to VP and OT secretion (just as they are in response to increased pOsm), and that removal of hypovolemia will remove the stimulus for VP and OT secretion. However, I would not be surprised to find that in a dog only VP is secreted, just as in increased pOsm. A quick search turned up no information, and I believe I have asked this question before and that there was no data on the issue. If there is no dog data, I would be shocked to find there is any human data, and I have been unable to find any.
Similarly, I am not aware of any data indicating that an increase in vascular volume would acutally
inhibit VP or OT secretion. Repair of hypovolemia will indeed remove the stimulus for their secretion, but in the context of a pregnancy, I am willing to bet money that it is simply not known how an increase in vascular volume would effect baseline OT secretion, when the baseline OT level is already influenced by pregnancy. My guess is that by repairing the loss in volume from the GSW (and I doubt 1L of fluid is enough to even reach normal volume, and only transiently if at all), you would simply return to the normal baseline OT level, rather than actually inhibiting OT.
Overall, unless there is new data that I haven't seen, it's unlikely that we know for sure how the loss of blood, or subsequent infusion of NS would affect the OT levels in this patient. I'd be surprised to learn that there is any new information, as the studies relating to volume and OT are all pretty old. If there is new information, I'd love to see it (serious, not sarcastic).
Your suggestion does strike me as incredibly interesting for another reason: it raises the question of the effect of hypovolemia on OT levels in a pregnant patient, and the possibility that hypovolemia may encourage parturition. I have no idea what blood level of OT we are talking about here, or even if hypovolemia does effect OT, as discussed, but my curiosity is certianly up. Very quick search turned up nothing of interest, unfortunately. Again, I'd love to see any relevant data.
EDIT:
I did a bad quick search....just found a few relevant articles...only had time to scan, but it appears as if hydration has little effect on preventing pre-term labor....which goes along with most of what I've said. None look like they directly address the OT mechanism.