I think this is a really cool idea, but we've done one podcast and it was almost a month ago... I know Rob was probably busy studying for his NP exam(Congrats), but I think momentum needs to pick up a bit here. Otherwise I see this dying out soon...
Although I know its been discussed in depth several times over and over again ten-fold, i think its something that is very important as it is one of the major misconceptions in EMS, I myself didn't know to search for it until recently when I began wondering why the nurse kept taking of my NRB every time i brought someone into the ER.
--Oxygen and it's Overuse.
Next topic will be, "Rescuscitative Endocrinology: Sex Hormones in Prehospital Medicine".
After that, it will most likely be, "Oxygen: The Most Abused Drug in EMS", but don't quote me on that just yet.
Some Selected Readings on the Topic
Sex, Drugs and R & R (Resuscitation & Reanimation) JEMS Article
http://www.jems.com/article/administ...r-resuscitatio
Rationale for routine and immediate administration of intravenous estrogen for all critically ill and injured patients.
Wigginton JG, Pepe PE, Idris AH. Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas TX, USA.
http://www.ncbi.nlm.nih.gov/pubmed/21164406
Estrogen enhances neurogenesis and behavioral recovery after stroke.
Li J, Siegel M, Yuan M, Zeng Z, Finnucan L, Persky R, Hurn PD, McCullough LD.
J Cereb Blood Flow Metab. 2011 Feb;31(2):413-25. Epub 2010 Oct 13.
http://www.ncbi.nlm.nih.gov/pubmed/20940729
Wigginton JG, Pepe PE, Bedolla JP, et al. Sex-related differences in the presentation and outcome of out-of-hospital cardiopulmonary arrest: A multiyear, prospective, population-based study. Crit Care Med. 2002;30 Suppl:S131–S136.
Wigginton JG, Pepe PE, Idris AH.
Higher resuscitation rates for women of child-bearing age following out-of-hospital cardiopulmonary arrest (Abstract). (Originally titled: Potential pharmaco-biological and hormonal effects on resuscitation.) Acad Emerg Med. 2006;13 Suppl:174.
Topjian AA, Localio R, Berg RA,
National Registry of CPR. Women of child-bearing age have better in-hospital cardiac arrest survival outcomes than equal aged men. (Submitted for peer-review)
Wigginton JG, Pepe PE, Idris AH. Sex-related differences in response to global ischemic insult and treatment. In Vincent JL (ed): 2007 Yearbook of Intensive Care and Emergency Medicine. Springer-Verlag: Berlin-Heidelberg, 2007. p. 880–888.
Lu A, Ran RQ, Clark J, et al. 17-beta-estradiol induces heat shock proteins in brain arteries and potentiates ischemic heat shock protein induction in glia and neurons. J Cereb Blood Flow Metab. 2002;22:183–195.
Mizushima Y, Wang P, Jarrar D, at al. Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals. Ann Surg. 2000;232:673–679.
Yu HP, Shimizu T, Choudhry MA, et al. Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: Up-regulation of cardiac heat shock factor-1 and heat shock proteins. J Mol Cell Cardiol. 2006;40:185–194.
Chae SU, Ha KC, Piao CS, et al. Estrogen attenuates cardiac ischemia-reperfusion injury via inhibition of calpain-mediated bid cleavage. Arch Pharm Res. 2007;30:1225–1235.
Suzuki T, Yu HP, Hsieh YC, et al. Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage. Cytokine. 2008;42:32–38.
Hsieh YC, Frink M, Hsieh CH, et al. Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1227–L1232.
Meldrum DR. G-protein-coupled receptor 30 mediates estrogen's nongenomic effects after hemorrhagic shock and trauma. Am J Pathol. 2007;170:1148–1151.
Sener G, Arbak S, Kurtaran P, et al. Estrogen protects the liver and intestines against sepsis-induced injury in rats. J Surg Res. 2005;128:70–78.
Simpkins JW, Wang J, Wang X, et al. Mitochondria play a central role in estrogen-induced neuroprotection. Curr Drug Targets CNS Neurol Disord. 2005;4:69–83.
Yang SH, Shi J, Day AL, et al. Estradiol exerts neuroprotective effects when administered after ischemic insult. Stroke. 2000;31:745–749.
O'Connor CA, Cernak I, Vink R. Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats. Brain Res. 2005;1062:171–174.
Sribnick EA, Wingrave JM, Matzelle DD, et al. Estrogen attenuated markers of inflammation and decreased lesion volume in acute spinal cord injury in rats. J Neurosci Res. 2005;82:283–293.
Messingham KA, Heinrich SA, Kovacs EJ. Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production. J Leukoc Biol. 2001;70:887–895.
Ozveri ES, Bozkurt A, Haklar G, et al. Estrogens ameliorate remote organ inflammation induced by burn injury in rats. Inflamm Res. 2001;50:585–591.
Wigginton J, Saner K, Schug K, et al. Sex steroid level alterations in the blood and cerebrospinal fluid following severe traumatic brain injury. Circulation. 2009 (in press).
Wright DW, Kellermann AL, Hertzberg VS, et al. ProTECT: A randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med. 2007;49:391–402.
Gatson JW, Maass DL, Simpkins JW, et al. Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling. J Neuroinflammation. 2009;6:30.