(First of all, dissection ≠ aneurysm. A dissection can look somewhat "aneurysmal," but they are distinct entities, different epidemiology, different pathophys, clinical presentation, treatment, etc. )
A LR(+) of
5.7 is helpful, but let me talk a little bit more about where that number came from.
The linked website (
LITFL) grabbed it from a review article published in JAMA in 2002 (
Does This Patient Have an Acute Thoracic Aortic Dissection?)
In that meta-analysis, they compile the results of three studies looking at pulse deficits (not blood pressure differential). 2 of the studies do not have statistically significant results for the LR(+). The positive study is
Von Kodolitsch et al, 2000
Now we're getting somewhere! This study enrolled 250 patients who had presented with chest or back pain, who were "considered clinically suspicious of acute aortic dissection by 2 experienced emergency department physicians," and who had negative work-ups for ACS, pneumothorax, or any other clear alternative diagnosis. This group, in other words, was at very high risk for aortic dissection, and the results bear that out -
128 of the
250 patients had a confirmed dissection. That's a
really high positive rate!
So, in this wicked high risk group, they found that 38% of the dissections had a pulse deficit
or BP differential, while only 1% of the non-dissections did. Their language leads me to believe that the BP differential wasn't actually as helpful as the simple presence/absence of a pulse, but they don't just come out and say it.
Soooo, if you have someone with severe chest/back pain who doesn't have ACS, PNA, PTX, PE, cholecystitis, etc., then a pulse deficit might be very helpful.