4. Am I certain that I can secure his airway?
5. What am I going to do if I give the drugs and then can't intubate?
If you don't ask those two questions along with the first three, you're heading towards a lawsuit.
Agreed, but this is not the answer to "when to intubate", the question the OP asked. These are the questions you ask yourself once you've decided that you've going to head down the DFI road. And let's be totally honest, it's a foolish provider that doesn't set himself up for success.
The answer to the questions that USA asked should be, "Yes, I'm sure I can secure the airway, if not with an ETT, then with a supraglottic rescue airway such as a Combi-Tube or a Cricothyrotomy. If I push the drugs and can't secure the airway with an ETT, I'll move right to the failed airway plan."
Every practitioner that even thinks about DFI should have a failed airway plan, with the rescue airway out and available.
When I do a DFI, and I'll admit, I've only done 7, I always have all of the tools I may require to secure the airway out and ready for use. That includes a bougie, a combi-tube, the Quick-Trach kit, a different blade, a size smaller tube, the suction on and the catheter at the ready...
A DFI isn't anything to be taken lightly... luckily I haven't had an airway prove to be so difficult that I can't manage it... yet. I'm sure that day will come, and every time I start to consider a DFI, I wonder if this will be the one that I can't get and will have to cut.
I am a firm believer that if I can manage the airway without a DFI, I will. Close proximity to the ED or an airway that looks very difficult after a LEMONS/BONES eval will give me pause. However, if the PT needs that tube, I'll do what needs to be done, knowing that I've got a couple of backup plans if things start to go sideways.