It's not "homemade racemic epi", it's simply nebulized Epi in saline. As I said above, racemic Epi is Epi that has both a "left-handed" and "right-handed" isomer... Better explained as chirality.
You can't just dump Epi into saline and whip that up. Regular L-Epi works just fine when nebbed up for croup.
O-chem came in handy at last.
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To add to this, an enantiomer is a hydrocarbon molecule where at least one carbon molecule has 4 different side chains, thereby forming a tetrahedral 3d shape (VSEPR can kiss my ____). Depending on which side chains are where, will depend on whether it's a L enantiomer or a D enantiomer. A racemic mixture is a mixture of both L and D enantiomer.
Since adding normal saline cannot result in a structural change of epinephrine, it cannot convert a chiral mixture (i.e. a mixture with more L or D enantiomers than the other enantiomer) to a racemic (equal L and D enantiomers) mixture.
You can use regular epi 1:1000 in a neb to treat croup, but it's not "racemic" unless it's a 1:1 mix of D and L chiral molecules.
"Regular" epi is the levorotatory isomer, and studies have shown it works just as well, but it's a higher dose. (5mg Epi in 2-5ml of NS)
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Starting premise is invalid. Both enantiomers are biologically active.
Rice PJ, Miller DD, Patil PN. Epinephrine enantiomers: affinity, efficacy and potency relationships in rat smooth muscle tissues. J Pmcol Expt Ther (1989) 249(1): 242-248
TABLE2 90
Receptor properties in rat tissues 80
EffICaCy is the reciprocal of fractional occupancy at ı Efficac? is expressed
as (pECı - plc). pECı. pK,, and efficacy values for rat aorta from Rice et a!. 70
(1987).
(-ıEınephıne (+).Epineph#{241}ne Ratio 60
Aorta
pECse 9.19±0.06 7.52±0.06 49±6
plc 7.69±0.10 6.10±0.10 55± 16
Efficacya 42±9 38±14 1.4±0.3
Efficacyb 1.50±0.12 1.42±0.12 1.1 ±0.2
Portal vein
pECse 7.40 ± 0.06 5.94 ± 0.10 40 ± 10
plc, 6.41 ± 0.12 5.30 ± 0.20 18 ± 7
Efficacy 12±3 10±4 2.4±0.7
Efficacyı 0.99 ± 0.13 0.64 ± 0.21 1.5 ± 0.5
Spleen
pECse 6.99±0.07 5.45±0.04 39±6
PKd 6.18±0.12 4.96±0.19 26±9
Efficacy 10±2 6±1 1.8±0.5
Efficac? 0.81 ± 0.14 0.49 ± 0.19 1.7 ± 0.2
Vas deferens
pECse 7.35 ± 0.04 5.83 ± 0.05 34 ± 2
plc, 6.15 ± 0.10 4.66 ± 0.10 23 ± 6
Efficacyı 23±6 19±4 1.7±0.3
Efficac? 1.20 ± 0.11 1.17 ± 0.11 1.0 ± 0.2
Hey Guys,
Could racemic epinephrine be "macgyvered" by mixing epi and NS in the appropriate amounts?
Thanks,
Rob
I'm curious... if you have a clue about O-Chem, why did you post about racemic Epi in the first place?