If one is good, two is better, and three fills up all the holes?
In all seriousness, if I'm running a BLS arrest with enough personnel, and there's good ventilation with BVM + OPAwith supplemental O2, good CPR in progress, and an AED attached, I don't see why *not* to stick in an extra NPA...
If it's respiratory distress, but the patient is conscious and being BVM'ed, why not double up on the NPAs, assuming they're tolerated? (I realize "why not" isn't necessarily evidence based -- on the other hand, I can't imagine that any harm would occur...)