Nitronox. Why isn't it used anymore?

bigbaldguy

Former medic seven years 911 service in houston
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Does anyone have past or current experience using nitronox (A mix of nitrous oxide 50% and oxygen 50%) in an EMS system? From what I've seen online it seems like the perfect treatment for pain in the prehospital system. Low risk of side effects, very little risk of drug seekers calling 911 for it, also helps alleviate anxiety. I've also noticed that it seems to be less used by dentists lately as well. Is it still used in any EMS system?
 
Does anyone have past or current experience using nitronox (A mix of nitrous oxide 50% and oxygen 50%) in an EMS system? From what I've seen online it seems like the perfect treatment for pain in the prehospital system. Low risk of side effects, very little risk of drug seekers calling 911 for it, also helps alleviate anxiety. I've also noticed that it seems to be less used by dentists lately as well. Is it still used in any EMS system?

I know it's still in the protocols here for both general pain management and fractures/dislocations, but not sure on how widely it's used as opposed to Morphine/Fentanyl. Here it's a BLS drug though, so it might see some wider use.
 
I loved having it. It takes effect within a couple of breaths, so it was great to pop someone on that while working on getting the IV and giving them morphine. Also good for people allergic to morphine (all we carried) or who didn't like opiates and/or wanted to control how much medication they got. I'm not sure if that agency is still using it or not.

As for why it isn't very common, the reason I hear is because it is almost impossible to account for. There isn't a very good way to track it and make sure no one is abusing it.
 
I see a few places on google that have protocols written for it but nothing about it actually being in use anywhere. It's like mast trousers in Texas we have to know how to use them but nobody even carries them anymore, but unlike mast trousers I can't find anything on why it's not used.
 
We used to have it known as "entonox" now we just have methoxyflurane as a substitute.
 
Maybe it has something to do with the health risks of long-term exposure to health care workers. We scavenge waste anesthetic gases in the OR, and have frequent spot-checks to measure N2O concentration in the OR. Unless you're using a closed system, there really is no way to scavenge the waste/exhaled gases.

MOF (methoxyflurane) is used almost exclusively in Australia and New Zealand as a method of self-administered pain control. It's an anesthetic gas with a high incidence of renal toxicity. It's use has been totally abandoned in the US - I don't think it's even commercially available here anymore.
 
I had it at my internship department, used it on many patients and loved it.

However, due to the FDA, the Oxygen and Nitrogen must be bottled separately and thus cost much more.
 
I had it at my internship department, used it on many patients and loved it.

However, due to the FDA, the Oxygen and Nitrogen must be bottled separately and thus cost much more.

Ahhh and there you have I bet. Cost issue?
 
Maybe it has something to do with the health risks of long-term exposure to health care workers. We scavenge waste anesthetic gases in the OR, and have frequent spot-checks to measure N2O concentration in the OR. Unless you're using a closed system, there really is no way to scavenge the waste/exhaled gases.

MOF (methoxyflurane) is used almost exclusively in Australia and New Zealand as a method of self-administered pain control. It's an anesthetic gas with a high incidence of renal toxicity. It's use has been totally abandoned in the US - I don't think it's even commercially available here anymore.

Good info. Thanks.
 
Startup and maintenance costs high.

Bulky to store and may not be as easily carried to a rescue scene as morphine or fentanyl.

Risks to personnel unless a scavenger system used and ambulance is well vented. (already mentioned)

Patient must be able to self administer.

Long list of conditions (pneumothorax, COPD hx, chest trauma, head injuries, facial injuries, bowel obstruction, CHF) where it should NOT be used.
 
The number one reason is there's not a commercially available EMS friendly blender made anymore....
 
The number one reason is there's not a commercially available EMS friendly blender made anymore....

That department you used to work at is still using those antique blenders. When they get banged or dropped, everybody has a seizure cause they can't be replaced.
 
That department you used to work at is still using those antique blenders. When they get banged or dropped, everybody has a seizure cause they can't be replaced.

Those things were old when I worked there in 2004....
 
When I rode with St. John in Auckland (New Zealand) a coupe of weeks ago we gave one patient etonox. Patient was a 17 yo female who had sprained/possibly broken her ankle at a skating rink, no other complaints. Given this, the patient being hysterical, and the seven minute transport, the crew opted not to start and IV and use etenox along with PO liquid acetaminophen. In five minutes time 9/10 was reduced to 5/10 and patient was noticeably less anxious. I was fairly sold on it, it was in it's own D-tank sized cylinder that we just threw on the stretcher like you would oxygen when you get on scene. It had a mount right at the stretcher head so the patient could continue to use it during transport.

I was unaware of the potential for harm to providers however, obviously they do not see this as an issue down there. As with any drug, there are going to be contraindications so I don't see why that should stop its use.

A common theme on this board has been that the US EMS perspective on pain control is one of "all or nothing," and not everyone needs opiate based pain management. Perhaps entonox, with the proper delivery mechanism, could help fill this gap. It's a BLS drug in NZ too, the crew was shocked when I a) didn't know how to administer it and b) that we have ambulances in major urban areas that carry no more than pillows and cold packs for pain control.
 
Maybe it has something to do with the health risks of long-term exposure to health care workers. We scavenge waste anesthetic gases in the OR, and have frequent spot-checks to measure N2O concentration in the OR. Unless you're using a closed system, there really is no way to scavenge the waste/exhaled gases.

MOF (methoxyflurane) is used almost exclusively in Australia and New Zealand as a method of self-administered pain control. It's an anesthetic gas with a high incidence of renal toxicity. It's use has been totally abandoned in the US - I don't think it's even commercially available here anymore.

The renal and hepatic toxicity from methoxyflurane was only found at high doses required for anaesthesia. The low dose levels given as inhaled analgesia have been found to be safe provided you are not using the drug regularly.
 
The renal and hepatic toxicity from methoxyflurane was only found at high doses required for anaesthesia. The low dose levels given as inhaled analgesia have been found to be safe provided you are not using the drug regularly.

But in a litigious society like the US, that concern is more than enough to take it off the market. Even 30 years ago, it's use had become very limited here, and I probably haven't seen it in 25 years.
 
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I see a few places on google that have protocols written for it but nothing about it actually being in use anywhere. It's like mast trousers in Texas we have to know how to use them but nobody even carries them anymore, but unlike mast trousers I can't find anything on why it's not used.

So I take it CCEMS no longer carries it? I loved the stuff! Simple and effective with minimal side effects.
 
So I take it CCEMS no longer carries it? I loved the stuff! Simple and effective with minimal side effects.

Nope, haven't even heard of it mentioned. I'll have to ask next time I run across one of the old timers ;) Maybe I'll run into one while I'm taking the medic course.
 
IN Fentanyl is available. Entonox is not needed anymore.
 
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