I really don't to OPQRST/SAMPLE questions any more unless I absolutely have to. FWIW, half the time I have no idea why my patient is in one of my rooms in the ER beyond "leg pain" or "cough." I just look at the census board, notice that I have a new patient and off I go to assess my new patient. I pretty much start each contact the same way. "Hi, I'm Akulahawk, and I'll be your nurse for today. What brings you in to the ER today?" I'll then let the patient talk about their problem. I'll ask some clarifying questions along the way and I'll usually ask about pain, nausea/vomiting, dizziness, shortness of breath, tingling or numbness, problems with peeing/pooping (GI or GU problems, just to check other systems that aren't related to the complaint. The meat of the questions really happen when I'm doing a more focused assessment on a particular system that is likely involved with a given complaint. The more you know about A&P and pathophys, the more specific you'll be able to ask questions about various problems. You should, if possible, hang around nearby when one of the providers does their evaluation because sometimes you'll notice questions that are good ones to ask...