The brain does not metabolize glucose differently, however, glucose is the sole source of energy for cerebral cells, hence one of the many reasons hyopglycemia causes altered mental status.
...But here's the thing, most cells can use fatty acids or proteins in this process should there be a deficit of glucose.
..... brain cells only get there energy from glucose.
ok... that makes a lot of sense...
now, does the brain utilize insulin in the same manner as the rest of the body?
And I think this is the most relevant at the basic level. The brain is limited to burning sugar. The rest of the body can use alternative fuels when sugar is low.