I agree with the holding of pressors. In order for them to work well, the tank needs to be full. It sounds like you were behind the 8 ball before you even walked in the door.
In our system, RSI is only standing orders if three criteria are met: 1) GCS less than or equal to 8 2) unable to maintain 90% or higher SPO2 with high flow oxygen and/or assisted ventilations 3) greater than 10 minute transport time. If all 3 criteria are not met, then we must call and ask for permission. For less than 10 minutes transport (which is almost always for me) it is almost always denied.
As for the source of the sepsis, I believe the 4 most common sources are renal/urinary, respiratory, abdominal/peritoneal, and CNS. I've heard the residents lectured that if they don't find the source in one of those 4 areas, go back and look, it is likely it was missed.
Smash is very wise. Dr. Emanuel Rivers at Henry Ford is the source of much of our current theory on sepsis and EGDT.
I also would not go with Narcan, since she is not an overt narcotic OD, and we are able to maintain her sats with assisted ventilations. It sounds likely for her to be a polysubstance abuser, so removing the narcotic (even though it wasn't there) and allowing the coke and meth to have unchallenged sympathetic overdrive would not make your job any easier.