Ambient pressure affects things a great deal, depending on how you look at it. A pressurized Learjet cabin may have an internal "altitude" of 6000' when flying at 37,000", which affects any gas occupying lesion such as bowel obstructions, closed pneumothoraces, pneumomediastina, etc. In the event that we have to fly with a sea level cabin, we fly the plane at 25,000-28,000, which greatly affects the fuel consumption by 30%.
It can also affect flowmeters since they are calibrated to 50 PSI gas source to room air, but at altitude, they can "under-read" due to lower gas density. You really have to know why things work more than how things work in order to stay out of the weeds, including the mechanics of your equipment and patient.