Another citationed Wikipedia article, this one on high flow therapy
http://en.wikipedia.org/wiki/High_Flow_Therapy
AND I QUOTE:*
" Nasal cannulae used for oxygen delivery usually deliver 1–6 liters of oxygen per minute. The FiO2 the percent oxygen inhaled by the patient, usually ranges roughly from 24% to 35% as the 100% O2 delivered from the cannula is diluted by ambient air (21% oxygen). Flow rates for delivery of oxygen using typical nasal cannula are limited because medical oxygen is anhydrous, and when delivered from a pressurized source the gas cools as it expands with the drop to atmospheric pressure. Delivery of cold dry gas is irritating to the respiratory mucosa, can cause drying and bleeding of the nasal mucosa, trigger bronchospasm in asthmatics, and can increase metabolic demand by cooling the body. Thus oxygen delivery by nasal cannula is limited to less than 6 liters per minute.[2]
Even with quiet breathing, the inspiratory flow rate at the nares of an adult usually exceeds 12 liters a minute, and can exceed 30 liters a minute for someone with mild respiratory distress. The typical upper limit of oxygen delivery via nasal cannula of six liters a minute does not meet the inspiratory flow rates of the average adult and therefore the oxygen is then diluted with room air during inspiration. Prior to the advent of High Flow Therapy (HFT), when high FiO2 was required for respiratory support special face masks or intubation was required. With HFT, the goal is to deliver a respiratory gas flow volume sufficient to meet or exceed the patient's inspiratory flow rate. The gas is heated and humidified to give comfortable delivery of the respiratory support….
HFT requires the use of nasal cannulae and a system designed to deliver high flow rates and the pressure generated to do so. At the same time the nasal cannula must be small enough that they do not occlude more than 50% of the nares, as this allows flow during exhalation and flush out of end-expiratory CO2 to be removed from the nasopharyngeal cavity. If the cannula did seal, the high flow volume could prevent the removal of end-expiratory CO2 and potentially produce excessive pressure in the airway which may result in barotrauma."
ENDQUOTE
Citations:
McGinley, B.; Halbower, A.; Schwartz, A. R.; Smith, P. L.; Patil, S. P.; Schneider, H. (2009). "Effect of a High-Flow Open Nasal Cannula System on Obstructive Sleep Apnea in Children". Pediatrics 124 (1): 179–188. doi:10.1542/peds.2008-2824. PMC 2885875. PMID 19564298.
Waugh, J. B.; Granger, W. M. (2004). "An evaluation of 2 new devices for nasal high-flow gas therapy". Respiratory care 49 (8): 902–906. PMID 15271229.
Roca, O.; Riera, J.; Torres, F.; Masclans, J. R. (2010). "High-flow oxygen therapy in acute respiratory failure". Respiratory care 55 (4): 408–413. PMID 20406507.
Waugh, J. B.; Granger, W. M. (2004). "An evaluation of 2 new devices for nasal high-flow gas therapy". Respiratory care 49 (8): 902–906. PMID 15271229.
McGinley, B. M.; Patil, S. P.; Kirkness, J. P.; Smith, P. L.; Schwartz, A. R.; Schneider, H. (2007). "A Nasal Cannula Can Be Used to Treat Obstructive Sleep Apnea". American Journal of Respiratory and Critical Care Medicine 176 (2): 194–200. doi:10.1164/rccm.200609-1336OC. PMC 1994212. PMID 17363769.
Shoemaker, M. T.; Pierce, M. R.; Yoder, B. A.; Digeronimo, R. J. (2007). "High flow nasal cannula versus nasal CPAP for neonatal respiratory disease: A retrospective study". Journal of Perinatology 27 (2): 85–91. doi:10.1038/sj.jp.7211647. PMID 17262040.
Kubicka, Z. J.; Limauro, J.; Darnall, R. A. (2008). "Heated, Humidified High-Flow Nasal Cannula Therapy: Yet Another Way to Deliver Continuous Positive Airway Pressure?". Pediatrics 121 (1): 82–88. doi:10.1542/peds.2007-0957. PMID 18166560.
*Wonder why I try to always include "AND I QUOTE"? I was told once here that simple quotation marks weren't enough. Just toeing the line.