House of God is only a miserable book if you don't experience medical school. Pretty much all of the caricature in that book (EMD Eddie or Jo or the Fat Man or the laid back ICU attending near the end) I've seen in the short past 6 months. Not counting the insanity of spending 80+ hours a week in the hospital where you literally go home, sleep, wake up, go back to the hospital (bite me general surgery... bite me... 5am to 6pm 13 days straight with 2 30 hour shifts in there 5am to 11am the next day). It's a miserable experience because many aspects of rotations and residency are miserable.
Oh I don't doubt it's accurate, and it's probably fine to read before or after you start school. It just has a heavy focus on the miserable/insane bits of medicine, and I don't see the need to be reminded of the negatives.
I was only suggesting that once you decide to go down the path, you need to keep your drive and passion alive. Negativity can seep in, and at least for me, it's important to make a conscious effort to focus on the positives. I'll happily choose inspiration over realism. No need to try to get jaded too early.
Samuel Shem wrote a couple of other books too. I've only read "The Spirit of the Place" but I thought it was a much more productive (and productive) outlook on medicine.
For Sublime:
This defiantly can be done. Being "poor" isn't the end of the world.
That said, your wife's worries are extremely important...she needs to be "all in" too. Her worries may primarily "can we buy a house" now, but her concerns may change. She is going to have to make big sacrifices for a long time (not seeing you as much, contagious stress, time and effort taking care of kids when you may not be able to help out, and supporting the family financially).
She has to be "all in" too, and you need to keep focused on your family whatever you do. DO NOT let your relationship play second fiddle. I promise a divorce or even general home strife will make medicine much much much harder and make your life miserable.
Be realistic...if she doesn't want to make those sacrifices, take it seriously. It's her decision too: it will be hard for both of you, but you probably get more of the benefits. In all likelihood you aren't going to gain riches or fame by going to medical school - you do it for happiness.
If your wife isn't on board, happiness is probably not in the future. You're already married with kids....your family is more important than medicine at this point. You can have both, just keep your priorities in mind.