R-wave progression is one of the best tools to help distinguish early repolarization from LAD occlusion but, as others have indicated, absence of reciprocal changes is also important. Other indicators include a QTc on the short side of normal, well developed R-wave in lead V4, fish-hooked J-point (not always present), upwardly concave ST-elevation (be careful as this does not rule out STEMI).
Dr. Smith has a complex formula that seems to works very well.
(1.196 x STE at 60 ms after the J-point in V3 in mm) + (0.059 x computerized QTc) – (0.326 x R-wave Amplitude in V4 in mm)
A value greater than 23.4 is quite sensitive and specific for LAD occlusion.
Dr. Smith adds these qualifiers:
"It is critical to use it only when the differential is subtle LAD occlusion vs. early repol. If there is LVH, it may not apply. If there are features that make LAD occlusion obvious (inferior or anterior ST depression, convexity, terminal QRS distortion, Q-waves), then the equation MAY NOT apply. These kinds of cases were excluded from the study as obvious anterior STEMI. ST elevation (STE) is measured at 60 milliseconds after the J-point, relative to the PR segment, in millimeters."