I use saline flushes to dilute some meds quite a bit. While the outside of the flushes aren't sterile, the contents are, therefore they don't go on a sterile field. Mostly what I use them for is to dilute small volumes of a medication that needs to be given over a couple minutes, or if I need to have a better measure of control over the rate I give it. I've had patients ask for Benadryl to be given fast... I won't do it because I know why they want it pushed fast. They usually don't like me too much once they realize they're not going to get it rapid IVP. Sometimes I'll put the med into a 10 ml syringe, evacuate the air out of it, then dilute using the saline that's in a running line, but much of the time, my patients just have saline locks.
One of the things that irritate me greatly right now is that we don't have very many saline vials nor do we have many lidocaine vials. We give a lot of our antibiotics IVP over 3 minutes, preferably diluted in 10 mL sterile water. NS will work in a pinch, but it's less preferable. Why do I bring up lidocaine? Well, ceftriaxone hurts a LOT if not diluted with lidocaine and given IM. I've only given it twice with sterile water in my career so far and that's only because there was no way I could get lidocaine to dilute it with. My patients were warned but even then it's still darned close to torture to give it without lidocaine.