Pulse oximeters can give a falsely high reading in the presence of carbon monoxide binding to haemoglobin about 250 times more strongly than oxygen and, once in place, prevents the binding of oxygen. It also turns haemoglobin bright red. The pulse oximeter is unable to distinguish between haemoglobin molecules saturated in oxygen and those carrying carbon monoxide. False high readings are also always obtained from smokers - readings are affected for up to four hours after smoking a cigarette. Other sources of carbon monoxide include fires, car-exhaust inhalation and prolonged exposure to heavy-traffic environments.