While Promethazine is chiefly classified as an antiemetic, it is a long-acting derivative of phenothyiazine(an example, of a group of tranquilizing drugs with antipsychotic actions thought to act by blocking dopaminergic transmissions) with marked antihistaminic activity, and prominent sedative, amnesic and anti-motion sickness actions.
Unlike other drugs derived from phenothiazine, extra pyramidal effects are rare, though in higher doesages, the potential for toxicity is eual to that of other derivatives. Much like other antihistamines, promethazine exerts antiseritonin, anticholinergic, and local anestheitc properties. Antiemetic MOA, is thought to be depressing CTZ in the medulla.
Regarding being allergic to epi;
"I have an allergic reaction to epinephrine - I get heart palpitations, start shaking and sweating, and get a bad headache. Last time, I felt as though I was going to die!"-the above complaints are all adverse reactions of the drug.
It is impossible to be allergic to epinephrine (epinephrine is the same as adrenaline). Our bodies produce epinephrine all the time. If you were allergic to it, you'd be long dead before reading this.
On an interesting note I'm sure most of you know epinephrine and adrenaline are synonymous, but did you know this: Epinephrine is derived from the greek 'epi-' meaning above, and 'nephros' regarding the kidney. so at face value, epinephrine means above the kidney. Adrenalin is derived from the Latin roots ''ad- and 'renes' and literally means on the kidney.
So both adrenalin and epinephrine mean the exact same thing in 2 different languages
