broken stretcher
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ok maybe i was a little harsh, ill splint and if I'm in a good mood and you really could use it ill give you some O's while my partner straps you in to the stretcher
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ok maybe i was a little harsh, ill splint and if I'm in a good mood and you really could use it ill give you some O's while my partner straps you in to the stretcher
ok maybe i was a little harsh, ill splint and if I'm in a good mood and you really could use it ill give you some O's while my partner straps you in to the stretcher
Chest pain with no allergies to aspirin and if they aren't on any kind of blood thinners I'll give aspirin and maybe nitro depending on their pressure. Protocol says I have to check pressure first. I would give that on scene .
Vitals on scene as long as we are fast and can do it in our time window . I will out the leads on and get them sent ahead.
History as we go. Load blah blah blah.
My understanding is that ASA is safe to give with pt's on blood thinners as a one time administration. What I've read (correct me if I'm wrong) is that the ASA causes the Cuomadin (or other blood thinner) to become unbound and cause massive decrease in your pt's coagulability. Pt's on blood thinners are told not to take ASA for this reason but during a cardiac event my understanding is that this is a safe tx. Thoughts?
Matt
Aspiring makes the platelets less sticky. Less sticky platelets make clots less likely to form in areas with limited flow (like blocked coronary arteries). Platelets are the first step in a long, complex cascade of events that lead to a strong clot.
Coumadin blocks another step, much further down that cascade.
Patients on blood thinners with a high risk of coronary artery blockage aren't typically told not to take aspirin. It's really personally driven, knowing that aspirin is a major preventer of clot formation in coronary arteries.
My understanding is that ASA is safe to give with pt's on blood thinners as a one time administration. What I've read (correct me if I'm wrong) is that the ASA causes the Cuomadin (or other blood thinner) to become unbound and cause massive decrease in your pt's coagulability. Pt's on blood thinners are told not to take ASA for this reason but during a cardiac event my understanding is that this is a safe tx. Thoughts?
Matt
That is interesting. Do you have a reference?
Warfarin and aspirin are both highly protein bound (>95%, IIRC), so if aspirin were to have a much greater affinity for the plasma protein binding sites than does warfarin, the bound warfarin would be displaced from the proteins, the free fraction of drug would be increased, and the net result would essentially be the same as giving a large bolus of warfarin.
That said, I've never heard of warfarin being an absolute contraindication to aspirin, and I've always assumed that the danger of co-administration was related more to syngergistic anticoagulant effects than any direct or indirect interaction between the drugs.
My paramedic instructor mentioned this, one of the many things that I have no idea how she knows without having an MD... her lectures would go along the lines of "if the atmospheric pressure of Oxygen is 20.95%..." anyhow after some digging here's an article I came up with
"Medications such as aspirin and the NSAIDs, and high doses of penicillin and moxalactam can increase the risk of warfarin related bleeding by inhibiting platelet function. Aspirin posses the most significant risk due to its common use and its prolonged effect on platelets. The proposed mechanism of interaction involves the possibility that salicylates displace warfarin from plasma protein-binding sites. However, the transient nature of the interaction make the significance of this mechanism questionable as compared to aspirin's intrinsic effect on platelets. Aspirin and NSAIDs can also produce gastric erosions that increase the risk of serious upper gastrointestinal bleeding. Some of the available NSAIDs may have a lesser effect on coagulation than aspirin."
https://secure.pharmacytimes.com/lessons/200301-01.asp
Seems that the ASA has a higher affinity and displaces the Cuomadin, so in effect you are 'giving your pt' a bolus of anticoagulant AND causing the inhibitory A2 thromboxane effects intrinsic in the ASA... just how I remember it, think it might hold some merit?
Matt
Well, I'm no pharmacist myself, so I just go by what I read. It sounds from this like the displacement of warfarin is a transient and likely minor effect. I have to review anticoagulants over the next couple weeks so I'll keep this in mind and see if I come across anything about it in my texts.
Good find.
This isn't a peer review article, but a practical look at the clinical implication of ASA + anticoagulants (both classical and novel).DrJohnM said:My take home
Combining warfarin and aspirin increases the risk of bleeding. A review of the evidence reveals scant few groups of patients that enjoy a net clinical benefit from the combination. In patients with mechanical valves, acute coronary syndrome and recent coronary stents, the benefit (embolic prevention) seems to outweigh the burden (bleeding).
What I have learned from this eye-opening look at the evidence base is to be much more cautious about combining these drugs.
Again, could less be more?