Hepatic syndromes are rarely acute acute unless you are dealing with a toxicological syndrome, in which case you can do little in the field, so talk to poison control and transport. Otherwise... transport.
Hematological syndromes typically not acute acute unless it is a manifestation of toxicologically mediated coagulopathy, but then you treat that manifestation for what it is: stroke, AMI, DVT, PE, CVA, GIB/hemorrhagic hypovolemia... or an acute manifestation of a leukopoetic malignancy or immunosuppression which you then treat in the field for what it is: eg SIRS/sepsis etc.
Sickle cell crisis (in SCD/SCT) is a more unique one if you know what it is (the SCD patient usually knows... they may even say "I don't have a spleen anymore")... but it can present so many ways, but usually includes severe pain from vascular occlusion and often also presents with (impending) ischemic insult one or more organs appearing as AMI, AKI, TIA, acute splenic sequestration, or whatever... you can have comorbid infection as a result or a precipitating factor. Folks with SCD usually know what they have and they know that opioids help their pain. Don't treat them like an addict. Treat their pain and transport because potential vascular occlusions need further workup stat, particularly if they say the pain is atypical in severity or location, or they have additional signs/symptoms like jaundice, abnormal EKG, etc.
Altitude note: hypoxia should be corrected. At high altitude we see folks who have SCT but never had an crisis before suddenly in crisis.