Aspirin anti-platelet onset?

[R.O.P.]

Does anybody know how quickly the antithrombotic effects of ASA appear after buccal absorption?
The ways my pharmacology texts word it is still unclear to me.
Thanks!

 

[Thindian]

I have been told that the "quick-dissolve" aspirin soaks into the blood stream within 3-5 minutes and becomes effective immediately after. I've also been told that normal "swallow the pill" aspirin takes 30-60 minutes to become effective in the blood stream.

 

[medicdan]

Some (recent) discussion, based on whether the patient chews or swallows the aspirin.

First Cited here:
http://www.modernmedicine.com/moder...Article/detail/598537?contextCategoryId=40131
Discussed here:
http://theemtspot.com/2009/10/27/are-all-aspirin-created-equal/

 

[R.O.P.]

Thanks for the links. The article mentions levels of ASA being detectable after 45 minutes. I wonder just how fast it really does begin get into the bloodstream. I will look up the study itself this weekend.
I ask because, since it is administered it in the field for an AMI, I assumed that it had a rapid onset of action. My texts say it has an immediate COX-1 inhibition, but they are unclear on how fast the absorption is.

 

[R.O.P.]

Ok I tried looking up the study, but I can't seem to find it!
These links got me pretty close:
http://www3.interscience.wiley.com/journal/122296983/issue
http://www3.interscience.wiley.com/journal/122305342/issue
I would be very curious to see how rapid the absorption of aspirin is. The article summary links provided by EMT.Dan mention blood levels @ 45 min. But it also says levels were measured @ 5min; 10 min; etc. I would love to see some kind of table or graph of this.
Does anyone have access to this study?

 

[medicdan]

I can't post the studies publicly (I have an academic library access), but do a google scholar search for the main Author (Nordt), and "Aspirin", and you should see something applicable.

Good Luck!

Dan

 

[18G]

Aspirin at a dose of 324mg has an onset of action (antiplatelet) of 15-30mins.

 

[medicdan]

Cite? is that if chewed? swallowed? gargled? snorted?

 

[DV_EMT]

drugs.com states 1-2 hours for absorption... but i believe that that's only for oral. I'm still looking for the buccal/SL absorbtion