Why do antibiotics sometimes cause renal failure?

I'm guessing you run SPEC?
 
tchristifulli said:
Why?
Click to expand...

Quick response cause I'm on my phone...

ABXs belong to different classes based on mechanism of action. For example, aminoglycosides (gentamycin) work by inhibiting the ribosomes. The idea is to shut down protein synthesis in the high-metabolism bacteria growing wherever its growing. The problem with this strategy is that out own cells will be affected with the bacterial ones. Some of the most metabolically active cells in our body are found in the proximal tubule of the nephron and are not to happy without their ribosomes.
 
Nice page. Much better than PoF or the like. Keep it up.

Just got home. I'll crack my books in a few if nobody else has chimed in.
 
Thanks man, you interested in helping out with SPEC? We are always looking for knowledgable people to help out.
 
Some drugs are metabolized into toxic byproducts and can then cause damage (acetaminophen for example). There's a 2009 article that points to vancomycin inducing free radical formation in the kidneys (although, it isn't due to metabolism). As stated above, other antibiotics (the aminoglycocides) have some cross reactivity with our own biological processes.
 
Pm sent.
 
You must log in or register to reply here.
Back
Top