Yes, any abnormality in the size, inequality, or dialation/constriction is abnormal.
From emsresponder.com:
# Pupil is the black center of the eye - Amount of light that enters the eye changes the size
# Evaluate pupils for
* Size
* Equality
o Both equal in size
o Causes of unequal pupils: stroke, head injury, eye injury, artificial eye
* Reactivity
o Reacting to light by changing sizes
o Causes for lack of reactivity: drugs, lack of oxygen to the brain
# Dilated Pupils
* Become larger
* Allow more light into the eye
* Causes for dilated pupils: fright, blood loss, drugs, treatment with eye drops
# Constricted Pupils
* Become smaller
* Large amount of light gets into the eye