Sorry Venty - I didn't explain my comment very well.
Resolution of bronchospasm via any kind of inhaled therapy is dependent on them being able to inhale sufficient quantities for a therapeutic effect. So once the acute asthmatic becomes profoundly fatigued for example with very low inspiratory volumes ie very "tight" then neb therapy will be largely ineffective hence my comment to move to IV bronchodilator therapy as well corticosteroids etc.
Also there is the problem of self administration. With hypercapnoea/emerging hypoxia and acute anxiety the acute asthmatic for example will be battling with every breath and in my experience spending more time in dependent posturing efforts than wanting to hold something to their mouth. Our guidelines emphasize an open mouth breathing approach with neb mask and the switch to +/- IV therapy once the situation gets out of hand - ie clinically insp + exp bronchoconstriction or profound fatigue/poor RSA numbers.
I guess in a compliant pt managing self admin the best dose delivery method is what works - as you say lots to choose from.
As an aside Neb Adrenaline has been used in some ED's here to attack the severe asthmatic episode in particular at its core - ie the inflammation.
"Our Ambulance Docs (who include outside resp specialists) have debated this approach for many years but still fall back to bronchodilator therapy + steroids. Also we haven't changed from Neb mask or T piece delivery then IV therapy for years.
As I understand it even with complete relief of bronchospasm irrespective of how this is achieved, ie no wheezes whatsoever, a Pt's small airways can still be up to 50% obstructed.
Another interesting area of resp medicine suffice it to say
Cheers
MM
Too fatiqued? These patients you do not wait and see what the neb will do. You get your line in and be read to go with addtional fluids and/or meds. As well, you may consider supporting ventilation if you have that capability. CPAP does not always work on asthmatics and can even be dangerous for some. BiPAP(Respironics trade name) can help a little better but again needs to approached with caution for more air trapping and decreased hemodynamics.
Due to inflammation and thick secretions, you may not get clear breath sounds after an Albuterol treatment. The patient may still have wheezes several days later after antibiotics, steroids and continuous nebulizer treatments but has a greatly increased Peak Expiratory Flow Rate.
The mask, even with open mouth, does not always encourage adequate breaths. It rather encourages a passive attitiude of "I've given the med". If you only have one patient YOU can assist holding the nebulizer in place and making it an active therapy session. I do this even while starting an IV with a little creative positioning. However, some patients may become mouth breathers when nearing failure and the mask may work okay. Of course, it will still vary with the type of nebulizer and particle size or efficiency of its delivery.
The mouth piece also allows me in the hospital to attach adjunct devices such as PEP or Flutter to assist in airway opening or mucus clearing. We also don't like to encourage open mouth technique as we are now in the process of retraining patients to NOT do this method when they take their MDIs since the HFA propellant is lighter and may not make it to the airways if too far. Of course, a spacer or holding chamber is the preferred method.
If the patient is already on the steps of respiratory failure, mask or mouth piece may not work.
The person can make every attempt to breathe deeply with open mouth or mouth piece but the narrowing will still prevent airflow or particle distribution. That is when we bring in the heliox for ventilation assist and particle delivery with or without a ventilator. I've had asthma patients on heliox by ventilator for over a week to support ventilator and medicine delivery while whatever infection and inflammation was causing the narrowing of the airways.
Neb Adrenaline does not attack the inflammation. We have used that on and off for years until other bronchodilators came about. Nebulized corticosteroids can help with the process and are used earlier for the inflammation of the asthma and inflamed throats from repeated or bad intubation attempts. IV steroids are also started. For some asthmatics, antibiotics will be necessary to treatment more than just an inflammation. PNA makes for a bad time for any asthmatic.
Unfortunately many ED physicians (and PCPs) do not stay current with the latest asthma or COPD treatments. That is why we now have people who are asthma educators around to assist. If the educator is an RRT, RNs are still the larger number of educators, they have a direct link to a Pulmonologist as an additional consult.
Here are the EPR-3 guidelines. I believe they are similar to the Australian/NZ, European and Canadian guidelines since these are formed with international sharing of information. The U.S., of course, is often at a disadvantage when it comes to the newer meds or delivery methods that are already available in other countries. Also, keep in mind this is for asthma. When there are other disease processes such as other forms of COPD, the guidelines change which is why they are guidelines and not just recipes or protocols. We make our protocols from these guidelines for some initial treatment but then may choose other pathways as further assessment is done.
U.S. EPR-3
http://www.nhlbi.nih.gov/guidelines/asthma/index.htm
Australia/NZ
http://www.thoracic.org.au/glasthma.html
Canada
http://www.lung.ca/cts-sct/guidelines-lignes_e.php
For those who believe they know everything there is to know about "a nebulizer":
European article about nebulizers:
http://www.erj.ersjournals.com/cgi/reprint/18/1/228.pdf
Performance Comparison of Nebulizer Designs:
Constant-Output, Breath-Enhanced, and Dosimetric
http://www.rcjournal.com/contents/02.04/02.04.0174.pdf
Good overview:
Comparing Clinical Features of the Nebulizer,
Metered-Dose Inhaler, and Dry Powder Inhaler
http://www.rcjournal.com/contents/10.05/10.05.1313.pdf
Heliox nebulizer (relatively new)
http://www.rcjournal.com/abstracts/2007/?id=aarc07_60
Heliox and albuterol
http://www.rcjournal.com/abstracts/2003/?id=OF-03-262
Heliox and ventilators
http://www.rcjournal.com/contents/06.06/06.06.0632.pdf
An interesting case study (just to show off an every changing field of specialty medicine):
HELIOX ADMINISTRATION DURING HIGH-FREQUENCY JET VENTILATION