Hello! I was looking for studies or any supported scientific data/studies that shows why 1:10000 solution IV/IO is preferred in Arrest setting over 1:1000? I herd multiple accounts stating various things without any material to support it. Here is some of the things that I herd: 1-1:10000 has the Saline in it to help propel the medication further into the central circulation. Thus don't have to follow up with Syringe NS boluses. 2-1:1000 Epi given IV can cause phlebitis, necrosis and all kinds of havoc if given IV. Thus avoid giving 1:1 1mg per 1ml epi IV. 3- To avoid medication errors. Prefilled syringes offer idiot proofing. Science/Data backing would be appreciated why 1:10000 is the preferred solution in arrest setting.